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Ann M Kapoun Selected Research

tarextumab

1/2019A randomized phase II trial of nab-paclitaxel and gemcitabine with tarextumab or placebo in patients with untreated metastatic pancreatic cancer.
1/2019A phase 1 dose escalation and expansion study of Tarextumab (OMP-59R5) in patients with solid tumors.
5/2015Targeting Notch signaling with a Notch2/Notch3 antagonist (tarextumab) inhibits tumor growth and decreases tumor-initiating cell frequency.

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Ann M Kapoun Research Topics

Disease

20Neoplasms (Cancer)
03/2022 - 06/2006
5Pancreatic Neoplasms (Pancreatic Cancer)
10/2020 - 11/2007
5Fibrosis (Cirrhosis)
01/2020 - 03/2004
4Inflammation (Inflammations)
03/2008 - 03/2004
3Breast Neoplasms (Breast Cancer)
11/2020 - 10/2012
3Adenocarcinoma
10/2020 - 07/2007
3Heart Failure
01/2018 - 03/2004
2Nausea
03/2022 - 10/2020
2Fatigue
03/2022 - 12/2017
2Exanthema (Rash)
03/2022 - 10/2020
2Ovarian Neoplasms (Ovarian Cancer)
01/2019 - 01/2019
2Hypertension (High Blood Pressure)
01/2018 - 10/2007
2Glioma (Gliomas)
02/2009 - 07/2007
2Neoplasm Metastasis (Metastasis)
11/2007 - 07/2007
2Pulmonary Fibrosis (Fibrosing Alveolitis)
08/2006 - 04/2005
1Vomiting
10/2020
1Liver Cirrhosis (Hepatic Cirrhosis)
01/2020
1Thrombocytopenia (Thrombopenia)
01/2019
1Diarrhea
01/2019
1Pulmonary Hypertension
01/2018
1Spasm (Spasms)
12/2017
1Dysgeusia (Parageusia)
12/2017
1Adenoid Cystic Carcinoma (Cylindroma)
01/2017
1Leukemia
01/2017
1Small Cell Lung Carcinoma (Small Cell Lung Cancer)
01/2017
1Carcinogenesis
02/2016
1Colonic Neoplasms (Colon Cancer)
03/2011
1Colorectal Neoplasms (Colorectal Cancer)
03/2011
1Glioblastoma (Glioblastoma Multiforme)
02/2009
1Bone Marrow Failure Disorders
10/2008
1Anemia
10/2008
1Chronic Obstructive Pulmonary Disease (COPD)
03/2008
1Pneumonia (Pneumonitis)
03/2008
1Sepsis (Septicemia)
01/2008
1Pain (Aches)
01/2008
1Arthritis (Polyarthritis)
01/2008
1Asthma (Bronchial Asthma)
01/2008
1Pre-Eclampsia (Preeclampsia)
10/2007
1Idiopathic Pulmonary Fibrosis
08/2006
1Interstitial Lung Diseases (Interstitial Lung Disease)
08/2006
1Experimental Arthritis
07/2006
1Vascular Diseases (Vascular Disease)
12/2004
1Necrosis
10/2004
1Myocardial Ischemia (Ischemic Heart Diseases)
10/2004

Drug/Important Bio-Agent (IBA)

6Transforming Growth Factor beta (TGF-beta)IBA
02/2009 - 03/2004
5GemcitabineFDA Link
10/2020 - 10/2012
5Phosphotransferases (Kinase)IBA
03/2008 - 04/2005
5indole-5-carboxamide (SD 282)IBA
03/2008 - 10/2004
4Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2019 - 06/2006
4LigandsIBA
01/2018 - 12/2014
4SD-208IBA
10/2008 - 08/2006
3130-nm albumin-bound paclitaxelIBA
10/2020 - 01/2019
3Monoclonal AntibodiesIBA
01/2020 - 03/2011
3CateninsIBA
01/2020 - 07/2012
3tarextumabIBA
01/2019 - 05/2015
3p38 Mitogen-Activated Protein KinasesIBA
03/2008 - 02/2003
3Transforming Growth Factor beta Receptors (TGF beta Receptors)IBA
11/2007 - 04/2005
2Paclitaxel (Taxol)FDA LinkGeneric
11/2020 - 01/2019
2Bleomycin (Blenoxane)FDA LinkGeneric
01/2020 - 08/2006
2Carboplatin (JM8)FDA LinkGeneric
01/2019 - 01/2018
2demcizumabIBA
01/2018 - 12/2014
2Brain Natriuretic Peptide (Natrecor)FDA Link
01/2018 - 03/2004
2Dihydrotachysterol (AT 10)IBA
12/2017 - 12/2014
2Pharmaceutical PreparationsIBA
10/2012 - 04/2005
2Adenosine Triphosphate (ATP)IBA
03/2008 - 07/2007
2Mitogen-Activated Protein KinasesIBA
03/2008 - 07/2006
2CytokinesIBA
01/2008 - 07/2007
2Interleukin-6 (Interleukin 6)IBA
06/2006 - 03/2004
1NivolumabIBA
03/2022
1Aspartate Aminotransferases (Aspartate Transaminase)IBA
10/2020
1Recombinant Fusion ProteinsIBA
10/2020
1Carbon Tetrachloride (Tetrachloromethane)IBA
01/2020
1PlatinumIBA
01/2019
1navicixizumabIBA
01/2019
1Pemetrexed (MTA)FDA Link
01/2018
1prolylglutamic acidIBA
01/2017
1Biomarkers (Surrogate Marker)IBA
01/2017
1Immunoglobulin G (IgG)IBA
12/2014
1delta proteinIBA
10/2012
1Frizzled ReceptorsIBA
07/2012
1AntibodiesIBA
03/2011
1Cetuximab (Erbitux)FDA Link
03/2011
1Irinotecan (Camptosar)FDA LinkGeneric
03/2011
1ErbB Receptors (EGF Receptor)IBA
03/2011
1Transforming Growth Factor beta1 (TGF beta 1)IBA
10/2008
1Adrenal Cortex Hormones (Corticosteroids)IBA
03/2008
1SmokeIBA
03/2008
1SteroidsIBA
03/2008
1Dexamethasone (Maxidex)FDA LinkGeneric
03/2008
1Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
10/2007
1PteridinesIBA
07/2007
1Complementary DNA (cDNA)IBA
07/2007
1Collagen Type II (Type II Collagen)IBA
07/2006
1SCIO-469IBA
06/2006
1Transforming Growth Factors (Transforming Growth Factor)IBA
04/2005
1C-Reactive ProteinIBA
12/2004
1EnzymesIBA
10/2004

Therapy/Procedure

4Therapeutics
03/2022 - 11/2007
4Drug Therapy (Chemotherapy)
01/2018 - 02/2016
2Transplantation
02/2016 - 10/2012